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Nicotinamide Riboside – The Longevity Supplement
“If I had access to only one supplement, NR would be that supplement. The fact that it’s not more widely used and distributed I just can’t get over it.”
— Dr. Drew Pinsky, Chief Patient Officer at The Wellness Company
As we age, our cells experience a decline in energy production and repair capacity. This is largely due to reduced NAD+ (nicotinamide adenine dinucleotide) levels, driven by increased activity of enzymes that consume NAD+, chronic low-grade inflammation, mitochondrial damage, and oxidative stress. Sedentary lifestyles, poor dietary choices, excessive alcohol consumption, and chronic stress can all further deplete NAD+.
NAD+ Levels Decline with Age
After age 50, NAD+ levels decline by approximately 50%[1]. Studies suggest reductions of roughly 30–50% in later adulthood, with newborns and young adults having substantially higher NAD+ levels than older adults—though precise percentages vary by tissue type and sex.
NAD+ Levels Across the Lifespan[1]
| Life Stage | NAD+ Levels | Notes |
|---|---|---|
| Newborn, Childhood | Very high | Supports rapid growth and repair |
| Teens–Early 20’s | Peak | Maximum mitochondrial and repair capacity |
| 30’s–40’s | Noticeable decline | Increase in NAD+-consuming enzymes and metabolic stress |
| 50+ | Lower levels | Evident decline in tissue function |
Combat NAD+ Decline – Supplement with Nicotinamide Riboside
NR supplementation has been shown to boost NAD+ levels by up to 200%![2]
Supports Anti-Aging and Longevity Pathways[2,3]
- NAD+ fuels enzymes like sirtuins and PARPs, supporting gene regulation, DNA repair, and stress response.
Improves Mitochondrial Function[2,3]
- Restores mitochondrial efficiency, enhances stem cell regeneration, and delays signs of aging in animal models.
Promotes Metabolic Health[2,3]
- Regulates glucose and lipid metabolism. May benefit insulin sensitivity, fat tissue function, and oxidative balance.
Supports Vascular Health[2,3]
- Linked to improved arterial stiffness and blood pressure in older adults.
Protects Against Inflammation and Oxidative Stress[2,3]
- Helps reduce inflammatory cytokines and enhance protective gene pathways.
- May offer neuroprotection and support brain function.
Organ System Benefits[2,3]
- Reduces fatty liver disease
- Protects against diabetic neuropathy
- Preserves hearing from noise-related damage
- Supports cardiovascular health and prevents heart failure (in animal studies)
- Reduces nerve damage from chemotherapy
- Stimulates stem cell regeneration in muscles, brain, and hair follicles
Don’t Just Live Longer – Live Better
Don’t let your birth year dictate your vitality. With The Wellness Company’s Longevity formula, you get a premium, research-backed supplement that energizes your body and supports gut health. Created by Dr. Drew Pinsky, this holistic solution helps you not just live longer — but live better.
References
- McReynolds MR, Chellappa K, Baur JA. Age-related NAD+ decline. Exp Gerontol. 2020;134:110888. doi: 10.1016/j.exger.2020.110888.
- Freeberg KA, Udovich CC, Martens CR, et al. Dietary Supplementation With NAD+-Boosting Compounds in Humans. J Gerontol A Biol Sci Med Sci. 2023;78(12):2435-2448. doi: 10.1093/gerona/glad106.
- Mehmel M, Jovanović N, Spitz U. Nicotinamide Riboside—The Current State of Research and Therapeutic Uses. Nutrients. 2020;12(6):1616. doi: 10.3390/nu12061616.
Written by Brooke Lounsbury
