GHK-Cu: The Overlooked Healing Peptide

Unlike other creams that just provide relief, THERABLUE™ supports healing at the cellular level. With advanced AQUsome™ technology that penetrates the skin, it delivers deep, restorative pain relief and healing — whether the source is muscle, nerve, or joint pain. Combined with time-tested botanical analgesics, it is the perfect marriage of technology and nature.

One peptide that has been overlooked but has a remarkable ability to heal—with an outstanding safety profile even at high doses—is GHK‑Cu.

GHK‑Cu is a small, naturally occurring protein fragment that binds copper and can be used directly on sore joints to help them heal. Research shows that when applied topically or injected into a joint, it not only reduces inflammation but also helps “reset” tissue behavior toward a healthier, more balanced state.^[1]

GHK-Cu Benefits

• Balances gene expression
• Promotes wound-healing genes while suppressing pro-inflammatory genes
• Restores normal inflammatory balance

This Leads To:

• Joint healing, not just pain relief
• Accelerated wound healing
• Increased cell growth
• Improved healing of connective tissue
• Stimulation of nerve and blood vessel growth
• Improved skin regeneration from UV damage, injury, and stress
• Reduced free radical damage
• Neutralized oxidative stress
• Suppression of inflammatory gene expression
• Potent anti-pain activity

Topical Delivery Through AQAsome Nanotechnology

Using AQAsome technology, GHK-Cu is delivered deep into tissues, targeting the root causes of inflammation and pain. Research shows impressive results when applied over tendons or arthritic joints, providing measurable relief.

High Safety Profile

Unlike oral pain relievers that may cause nausea, ulcers, or gastrointestinal bleeding, GHK-Cu shows a favorable safety profile—even at high doses.

Why THERABLUE™?

THERABLUE™ fuses advanced peptide technology with time-tested botanical analgesics, addressing inflammation and restoring cellular energy.

Key Active Components

Peptides

• Methylene Blue: Enhances mitochondrial energy and reduces oxidative stress linked to muscle fatigue.^[2]
• AQA NAD+: Restores cellular energy metabolism to support recovery, endurance, and resilience.^[3]

Botanical Analgesics

• Menthol, camphor, eucalyptus: Cooling relief and reduced pain perception.^[4]
• Arnica & white willow bark: Natural anti-inflammatories that reduce swelling, bruising, and stiffness.^[5,6]
• MSM: Supports joint flexibility and reduces chronic inflammation.^[7]
• Turmeric & ginger: Improve mobility and circulation while reducing inflammation.^[8,9]
• Capsaicin & black pepper extracts: Enhance circulation and improve absorption of other active ingredients.^[9,10,11]
• Castor oil: Enhances transdermal delivery, reduces inflammation, and provides natural pain relief.^[12,13]

The THERABLUE™ Difference

• Fast-Acting Relief: Cooling comfort begins within minutes.
• Deep Tissue Recovery: Peptides and botanicals restore balance at the cellular level.
• Clean & Gentle: No harsh chemicals, grease, or stains.
• Vegan & GMO-free
• Free of Common Allergens: Milk, eggs, peanuts, tree nuts, fish, crustaceans, wheat, soy, sesame.
• Contains Vitamin E: Supports skin integrity and protects against oxidative damage.
• Soothing Aromatic Blend: Chamomile, cinnamon, and yuzu oils.

How to Use

Apply a thin layer to affected areas 3–4 times daily. Massage until absorbed. Wash hands after use. Avoid using with other topical products or applying hot/cold packs immediately afterward.

References

1. Pickart L, Margolina A. Regenerative and Protective Actions of GHK-Cu Peptide. Int J Mol Sci. 2018.
2. Poudel SB et al. Targeting mitochondrial dysfunction to improve skeletal aging. Aging. 2024.
3. Covarrubias AJ et al. NAD+ metabolism in aging. Nat Rev Mol Cell Biol. 2021.
4. Finlay L. The science behind camphor, menthol, eucalyptus. Rupa Health. 2025.
5. Willow bark. ADAM Health Encyclopedia. 2025.
6. Arnica overview. WebMD.
7. Butawan M et al. MSM: Applications and Safety. Nutrients. 2017.
8. Kim S et al. Anti-inflammatory effects of curcumin. Front Pharmacol. 2021.
9. Heidari-Beni M et al. Herbal formulation for knee OA. Phytother Res. 2020.
10. ResearchGate: Piperine skin permeation study.
11. McCarty MF et al. Capsaicin and metabolic health. Open Heart. 2015.
12. Mein EA et al. Transdermal absorption of castor oil. 2005.
13. Alaayedi MH et al. Castor oil permeability effects. Int J Appl Pharm. 2018.

Written by Brooke Lounsbury