Ultra NAC, the Perfect Complement to Ultimate Spike Detox

When dealing with long COVID or vaccine injury, Ultimate Spike Detox can help detoxify and remove harmful free radicals. While that is essential, it is only part of the story. As your body recovers from the devastating effects of either long COVID or vaccine injury, it needs specific building blocks to regain health. Ultra NAC gives your body what it needs to further clear damaged cells, fortify defenses, and rebuild new, healthy cells.

Targeted relief

Whether you are dealing with long COVID or are a victim of vaccine injury, the ingredients in Ultra NAC are formulated to work in synergy to target symptoms and pathologies associated with both.

The combination of these seven ingredients targets three mechanisms:

• Oxidative Stress & Mitochondrial Dysfunction: (NAC, Glutathione, Selenium) : NAC and Glutathione provide raw antioxidant power; Selenium activates the enzymes that use that power.
• Spike Protein Persistence & Inflammation: (Quercetin, Zinc, NAC) target viral components directly.
• Enzymatic & Detoxification Support: (Molybdenum, Milk Thistle) Molybdenum clears the toxic byproducts of that process and silymarin supports this clearance and protects the liver.

How each works independently

1. Zinc

Zinc works as a modulator of the immune system and also has powerful antiviral properties. It inhibits the enzyme coronaviruses use to replicate. In long COVID, zinc deficiency acts as a bottleneck for immune function, preventing the resolution of chronic inflammation (1).

2. Selenium

Without selenium, glutathione cannot neutralize free radicals. Research indicates that SARS-CoV-2 depletes selenium in order to produce viral proteins, leading to "acquired selenium deficiency." This deficiency is linked to hyper-coagulation (blood clotting) and increased severity of illness (2).

3. Molybdenum

Molybdenum is the "cleanup crew" for sulfur metabolism. It is the essential cofactor for Sulfite Oxidase (SUOX), an enzyme that converts toxic sulfites (SO3) into harmless sulfates (SO4) (3).

This ingredient is included specifically to support the high doses of sulfur-containing antioxidants (NAC and Glutathione) in this protocol. Without adequate molybdenum, increasing sulfur intake can lead to "sulfite toxicity," causing headaches, brain fog, and flushing—symptoms often mistaken for a "Herxheimer" or detox reaction (4,5).

4. N-Acetylcysteine (NAC)

• Glutathione Precursor: It provides the cysteine needed to synthesize glutathione intracellularly (5).
• Disulfide Bond Disruption: Recent in vitro studies suggest NAC may disrupt bonds that hold the SARS-CoV-2 spike protein together, potentially altering its structure and reducing its ability to bind to ACE2 receptors (6).
• In Long COVID: NAC is a mucolytic (breaks down mucus) and reduces IL-6, a key inflammatory cytokine associated with the "cytokine storm" and chronic post-viral inflammation (7).

5. Milk Thistle Seed Extract (Silymarin)

• Silymarin is a hepatoprotectant (liver protector). It blocks toxins from entering liver cells and stimulates protein synthesis for liver repair.
• Emerging research suggests Silymarin may bind directly to the ACE2 receptor, potentially blocking viral entry and replication. As the body processes spike proteins or viral debris, the liver's detoxification load increases; Silymarin supports this clearance phase (8,9).

6. Liposomal Glutathione

• Glutathione is the body's "master antioxidant." The liposomal form encapsulates the molecule in a lipid (fat) layer, allowing it to bypass digestive destruction and enter cells directly.
• Long COVID patients often show severe glutathione depletion (oxidative stress). While NAC helps the body make glutathione, liposomal glutathione provides it directly, to exhausted cells (10).

7. Quercetin Dihydrate

Quercetin is a flavonoid with three distinct actions:

1. Zinc Ionophore: It opens channels in cell membranes, allowing ionic zinc to enter cells where it can inhibit viral replication (1).
2. Anti-inflammatory: It inhibits histamine release, which is common in long COVID patients with MCAS (Mast Cell Activation Syndrome) (11).
3. Senolytic Activity: It helps clear "senescent" (zombie) cells that persist after infection and drive chronic inflammation (12).

Synergy- Better together

The "Zinc Shuttling" System (Quercetin + Zinc)

• Zinc has difficulty entering cells on its own. It is water-soluble, while cell membranes are made of fat. Quercetin acts as the "bus" (ionophore) that transports Zinc (the passenger) across the fat-soluble cell membrane. This allows zinc levels to significantly rise within the cells, leading to inhibition of viral replication and regulation of immune signaling (1).

The Sulfur Detoxification Chain (NAC + Glutathione + Selenium + Molybdenum)

This is the most critical synergy for safety and efficacy.

1. Input: You take NAC and Liposomal Glutathione to flood the body with antioxidants.
2. Neutralize and bind: Selenium binds to glutathione to form Glutathione Peroxidase, the active enzyme that neutralizes viruses and oxidative damage. Without Selenium, the NAC/Glutathione is largely potential energy waiting to be used (12,13).
3. Waste Management: As glutathione fights toxins, it is broken down into sulfur byproducts (sulfites). If these build up, they are neurotoxic. Molybdenum activates the enzyme (Sulfite Oxidase) that clears these sulfites. Without Molybdenum, high-dose NAC/Glutathione can cause sensitivity reactions (14).

Pairing Ultimate Spike Detox with Ultra NAC gives your body what it needs to get you back to that pre-COVID feeling.

References

1. Velthuis, A. J., van den Worm, S. H., Sims, A. C., Baric, R. S., Snijder, E. J., & van Hemert, M. J. (2010). Zn(2+) inhibits coronavirus and arterivirus RNA polymerase activity in vitro and zinc ionophores block the replication of these viruses in cell culture. PLoS pathogens, 6(11), e1001176. https://doi.org/10.1371/journal.ppat.1001176
2. Hiffler, L., & Rakotoambinina, B. (2020). Selenium and selenoprotein deficiency in COVID-19: A plausible etiopathogenic mechanism for acute respiratory distress syndrome? Medical Hypotheses, 143, 109878. https://doi.org/10.1016/j.mehy.2020.109878
3. Oliphant, K. D., Fettig, R. R., Snoozy, J., Mendel, R. R., & Warnhoff, K. (2023). Obtaining the necessary molybdenum cofactor for sulfite oxidase activity in the nematode Caenorhabditis elegans surprisingly involves a dietary source. The Journal of biological chemistry, 299(1), 102736. https://doi.org/10.1016/j.jbc.2022.102736
4. Mukwevho, E., Ferreira, Z., & Ayeleso, A. (2014). Potential role of sulfur-containing antioxidant systems in highly oxidative environments. Molecules (Basel, Switzerland), 19(12), 19376–19389. https://doi.org/10.3390/molecules191219376
5. Bavarsad Shahripour, R., Harrigan, M. R., & Alexandrov, A. V. (2014). N-acetylcysteine (NAC) in neurological disorders: mechanisms of action and therapeutic opportunities. Brain and behavior, 4(2), 108–122. https://doi.org/10.1002/brb3.208
6. Murae, M., Shimizu, Y., Yamamoto, Y., Kobayashi, A., Houri, M., Inoue, T., Irie, T., Gemba, R., Kondo, Y., Nakano, Y., Miyazaki, S., Yamada, D., Saitoh, A., Ishii, I., Onodera, T., Takahashi, Y., Wakita, T., Fukasawa, M., & Noguchi, K. (2022). The function of SARS-CoV-2 spike protein is impaired by disulfide-bond disruption with mutation at cysteine-488 and by thiol-reactive N-acetyl-cysteine and glutathione. Biochemical and biophysical research communications, 597, 30–36. https://doi.org/10.1016/j.bbrc.2022.01.106
7. Izquierdo-Alonso, J. L., Pérez-Rial, S., Rivera, C. G., & Peces-Barba, G. (2022). N-acetylcysteine for prevention and treatment of COVID-19: Current state of evidence and future directions. Journal of infection and public health, 15(12), 1477–1483. https://doi.org/10.1016/j.jiph.2022.11.009
8. A mechanistic review on silibinin/silymarin in COVID-19 notes that silymarin “may block the protein–protein interaction between viral spike glycoprotein and host ACE2” at the receptor-binding domain interface, potentially reducing viral entry
9. Musazadeh, V., Karimi, A., Bagheri, N., Jafarzadeh, J., Sanaie, S., Vajdi, M., Karimi, M., & Niazkar, H. R. (2022). The favorable impacts of silibinin polyphenols as adjunctive therapy in reducing the complications of COVID-19: A review of research evidence and underlying mechanisms. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 154, 113593. https://doi.org/10.1016/j.biopha.2022.113593
10. Glassman, I., Le, N., Mirhosseini, M., Alcantara, C. A., Asif, A., Goulding, A., Muneer, S., Singh, M., Robison, J., Guilford, F., & Venketaraman, V. (2023). The Role of Glutathione in Prevention of COVID-19 Immunothrombosis: A Review. Frontiers in bioscience (Landmark edition), 28(3), 59. https://doi.org/10.31083/j.fbl2803059
11. Saccon, T. D., Nagpal, R., Yadav, H., Cavalcante, M. B., Nunes, A. D. C., Schneider, A., Gesing, A., Hughes, B., Yousefzadeh, M., Tchkonia, T., Kirkland, J. L., Niedernhofer, L. J., Robbins, P. D., & Masternak, M. M. (2021). Senolytic Combination of Dasatinib and Quercetin Alleviates Intestinal Senescence and Inflammation and Modulates the Gut Microbiome in Aged Mice. The journals of gerontology. Series A, Biological sciences and medical sciences, 76(11), 1895–1905. https://doi.org/10.1093/gerona/glab002
12. Glassman, I., Le, N., Mirhosseini, M., Alcantara, C. A., Asif, A., Goulding, A., Muneer, S., Singh, M., Robison, J., Guilford, F., & Venketaraman, V. (2023). The Role of Glutathione in Prevention of COVID-19 Immunothrombosis: A Review. Frontiers in bioscience (Landmark edition), 28(3), 59. https://doi.org/10.31083/j.fbl2803059
13. Taylor, E. W., & Radding, W. (2020). Understanding selenium and glutathione as antiviral factors in COVID-19: Does the viral Mpro protease target host selenoproteins and glutathione synthesis? Frontiers in Nutrition, 7, 143. https://doi.org/10.3389/fnut.2020.0014
14. Zaki, M. S., Selim, L., El-Bassyouni, H. T., Issa, M. Y., Mahmoud, I., Ismail, S., Girgis, M., Sadek, A. A., Gleeson, J. G., & Abdel Hamid, M. S. (2016). Molybdenum cofactor and isolated sulphite oxidase deficiencies: Clinical and molecular spectrum among Egyptian patients. European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society, 20(5), 714–722. https://doi.org/10.1016/j.ejpn.2016.05.011

Written by Brooke Lounsbury