Unlocking Nature's Anti-Aging Arsenal
In the ever-evolving world of nutritional supplements, a groundbreaking combination has emerged, bringing together some of the most promising compounds for supporting overall health and longevity. This innovative supplement combines Nicotinamide Riboside (NR), Liposomal Glutathione, Resveratrol, Betaine HCl, and specific probiotic strains (BL21, LRa05, and LC86) to create a comprehensive approach to wellness.
Separately, each supplement is a powerhouse of health and vitality, when combined they are unmatched in their ability to take your health to the next level.
Nicotinamide Riboside (NR): The NAD+ Booster
Nicotinamide Riboside is an alternative form of vitamin B3 that has gained significant attention in recent years. Its primary benefit lies in its ability to boost levels of NAD+ (nicotinamide adenine dinucleotide) in the body. NAD+ is an essential coenzyme found in every cell, playing a vital role in various biological processes, including energy production, DNA repair, and cellular defense.(1)
As we age, our NAD+ levels naturally decline, which has been associated with various age-related health issues. By supplementing with NR, we may be able to:
- Support healthy aging
- Enhance cognitive function
- Improve cardiovascular health
- Boost metabolism and energy production
- May help protect against viral diseases (2)
Liposomal Glutathione: The Master Antioxidant
Glutathione is often referred to as the body's master antioxidant due to its powerful ability to neutralize free radicals and support detoxification. The liposomal form enhances absorption and bioavailability. Potential benefits of liposomal glutathione include: (3)
- Reducing oxidative stress
- Supporting immune function
- Promoting liver health and detoxification
Resveratrol: The Longevity Compound
Resveratrol, a polyphenol found in red wine and certain plants, has gained attention for its potential anti-aging properties. Research suggests that resveratrol may: (4,5,6,7)
- Support cardiovascular health
- Exhibit anti-inflammatory effects
- Potentially enhance cognitive function
- Assist in blood sugar regulation
- Improve bone density in postmenopausal women
Betaine HCl: Digestive Support
Betaine hydrochloride (HCl) is a compound that can help support healthy stomach acid levels. Adequate stomach acid is essential for: (8,9)
- Proper protein digestion
- Nutrient absorption, especially minerals
- Preventing the overgrowth of harmful bacteria in the gut
- Lower homocysteine levels, which in turn reduces cardiovascular risk markers
Probiotics: BL21, LRa05, and LC86
The inclusion of specific probiotic strains adds another layer of health support to this comprehensive supplement. Let's look at each strain:
- BL21 (Bifidobacterium longum)
- Bifidobacterium longum strains are generally associated with: (10)
- Supporting digestive health
- Enhancing immune function
- Potentially improving mood and cognitive function
- Lower inflammatory markers
LRa05 (Lacticaseibacillus rhamnosus)
- rhamnosus LRa05 has shown promising results in recent studies: (11)
- Potential anti-obesity effects by reshaping gut microbiota
- Reducing lipid accumulation in mice fed a high-fat diet
- Promoting liver carbohydrate metabolism
LC86 (Lacticaseibacillus paracasei)
Recent research on L. paracasei LC86 has revealed several potential benefits:(12)
- Mitigating age-related muscle weakness
- Improving cognitive function in aging models
- Modulating gut microbiota composition
Synergistic Effects
When combined, these components create a powerful synergy that may provide comprehensive health support:
Cellular Energy and Longevity: NR and Resveratrol work together to support NAD+ levels and activate longevity-associated pathways.
Antioxidant Protection: Liposomal Glutathione and Resveratrol provide potent antioxidant support, potentially enhancing each other's effects. Together they provide increased endogenous levels of vitamins C,E and A, which in turn supports immunity.(13)
Digestive Health: Betaine HCl supports stomach acid production, while the probiotic strains promote a healthy gut microbiome.
Metabolic Support: NR, Resveratrol, and the probiotic strains may work synergistically to support healthy metabolism and weight management.
Cognitive Function: NR, Resveratrol, and certain probiotic strains have been associated with cognitive benefits, potentially offering comprehensive brain support.
Anti-Inflammatory Effects: Several components in this supplement have demonstrated anti-inflammatory properties, which may contribute to overall health and longevity.
References:
Mehmel, M., Jovanović, N., & Spitz, U. (2020). Nicotinamide Riboside—The Current State of Research and Therapeutic Uses. Nutrients, 12(6), 1616.
Radenkovic D, Reason, Verdin E. Clinical Evidence for Targeting NAD Therapeutically. Pharmaceuticals (Basel). 2020 Sep 15;13(9):247. doi: 10.3390/ph13090247. PMID: 32942582; PMCID: PMC7558103.
Sinha, R., Sinha, I., Calcagnotto, A., Trushin, N., Haley, J. S., Schell, T. D., & Richie, J. P. (2018). Oral supplementation with liposomal glutathione elevates body stores of glutathione and markers of immune function. European Journal of Clinical Nutrition, 72(1), 105-111.
Csiszar A. Anti-inflammatory effects of resveratrol: possible role in prevention of age-related cardiovascular disease. Ann N Y Acad Sci. 2011 Jan;1215:117-22. doi: 10.1111/j.1749-6632.2010.05848.x. PMID: 21261649; PMCID: PMC3058481.
Mahjabeen W, Khan DA, Mirza SA. Role of resveratrol supplementation in regulation of glucose hemostasis, inflammation and oxidative stress in patients with diabetes mellitus type 2: A randomized, placebo-controlled trial. Complement Ther Med. 2022 Jun;66:102819. doi: 10.1016/j.ctim.2022.102819. Epub 2022 Mar 1. PMID: 35240291.
Wong RH, Thaung Zaw JJ, Xian CJ, Howe PR. Regular Supplementation With Resveratrol Improves Bone Mineral Density in Postmenopausal Women: A Randomized, Placebo-Controlled Trial. J Bone Miner Res. 2020 Nov;35(11):2121-2131. doi: 10.1002/jbmr.4115. Epub 2020 Jul 14. PMID: 32564438; PMCID: PMC7689937.
Thaung Zaw JJ, Howe PR, Wong RH. Long-term effects of resveratrol on cognition, cerebrovascular function and cardio-metabolic markers in postmenopausal women: A 24-month randomised, double-blind, placebo-controlled, crossover study. Clin Nutr. 2021 Mar;40(3):820-829. doi: 10.1016/j.clnu.2020.08.025. Epub 2020 Aug 27. PMID: 32900519.
McRae MP. Betaine supplementation decreases plasma homocysteine in healthy adult participants: a meta-analysis. J Chiropr Med. 2013 Mar;12(1):20-5. doi: 10.1016/j.jcm.2012.11.001. PMID: 23997720; PMCID: PMC3610948.
Guilliams TG, Drake LE. Meal-Time Supplementation with Betaine HCl for Functional Hypochlorhydria: What is the Evidence? Integr Med (Encinitas). 2020 Feb;19(1):32-36. PMID: 32549862; PMCID: PMC7238915.
Gai, Z., Liao, W., Huang, Y., Dong, Y., Hao, Y., Wu, Y., Zhang, H., Chen, W., & Zhang, H. (2023). Effects of Bifidobacterium BL21 and Lacticaseibacillus LRa05 on gut microbiota in type 2 diabetes mellitus mice. AMB Express, 13(1), 97. https://doi.org/10.1186/s13568-023-01603-1
Sun M , Wu T , Zhang G , Liu R , Sui W , Zhang M , Geng J , Yin J , Zhang M . Lactobacillus rhamnosus LRa05 improves lipid accumulation in mice fed with a high fat diet via regulating the intestinal microbiota, reducing glucose content and promoting liver carbohydrate metabolism. Food Funct. 2020 Nov 18;11(11):9514-9525. doi: 10.1039/d0fo01720e. PMID: 33063800.
Cai Y, Dong Y, Han M, Jin M, Liu H, Gai Z, Zou K. Lacticaseibacillus paracasei LC86 mitigates age-related muscle wasting and cognitive impairment in SAMP8 mice through gut microbiota modulation and the regulation of serum inflammatory factors. Front Nutr. 2024 May 30;11:1390433. doi: 10.3389/fnut.2024.1390433. PMID: 38873561; PMCID: PMC11169942.Reducing inflammatory markers
Biswas P, Dellanoce C, Vezzoli A, Mrakic-Sposta S, Malnati M, Beretta A, Accinni R. Antioxidant Activity with Increased Endogenous Levels of Vitamin C, E and A Following Dietary Supplementation with a Combination of Glutathione and Resveratrol Precursors. Nutrients. 2020 Oct 22;12(11):3224. doi: 10.3390/nu12113224. PMID: 33105552; PMCID: PMC7690269.
Written By Brooke Lounsbury
