The Science Behind Dr. McCullough's Mito Support Formula

The Science Behind Dr. McCullough's Mito Support Formula

Are you looking to optimize your physical performance, mental clarity, and overall energy levels? Consider Mito Support, a supplement designed by world-renowned Cardiologist and Chief Scientific Officer of The Wellness Company, Dr. Peter McCullough. Its formula includes five high-quality, American-made, science-supported ingredients which work synergistically to help already healthy people supercharge their energy levels and enhance their overall health. 



D-Ribose is a sugar that is naturally produced by the body and is important for the production of ATP, the body's main source of energy. D-ribose has been shown in double-blind, placebo-controlled trials to help improve muscle function, body composition and exercise performance [1]. 

Acetyl-L-Carnitine HCL  

Acetyl-L-Carnitine HCL is an amino acid that supports healthy brain function and energy metabolism. Both animal models and human studies support its efficacy in enhancing focus, concentration, and memory, making it a great choice for anyone looking to support cognitive health [2, 3]. 


According to a 2021 study, citicoline supplementation significantly improves cognitive performance on memory tasks. Researchers believe it does so by improving frontal lobe bioenergetics via enhanced synthesis of phosphatidylcholine, a key component of the cell membranes surrounding brain cells [4]. 

Coenzyme Q-10 

Coenzyme Q10 (CoQ10) is a fat-soluble, vitamin-like antioxidant that plays a vital role in converting food into energy, and protects our cells from damage associated with exposure to toxic free radicals. It has been shown to exert a protective effect on the heart through a variety of mechanisms, such as reduced blood pressure, improved endothelial function, and reduced blood lipids [5]. 

PQQ (Pyrroloquinoline Quinone Disodium Salt)

Pyrroloquinoline Quinone Disodium Salt is a compound that supports healthy energy metabolism and mitochondrial health. It has been shown to help improve physical energy and endurance, as well as reduce markers of inflammation [6]. 


[1] Van Gammeren, D., Falk, D., & Antonio, J. (2002). The effects of four weeks of ribose supplementation on body composition and exercise performance in healthy, young, male recreational bodybuilders: a double-blind, placebo-controlled trial. Current therapeutic research, 63(8), 486-495. 

[2] Suchy, J., Chan, A., & Shea, T. B. (2009). Dietary supplementation with a combination of α-lipoic acid, acetyl-L-carnitine, glycerophosphocoline, docosahexaenoic acid, and phosphatidylserine reduces oxidative damage to murine brain and improves cognitive performance. Nutrition research, 29(1), 70-74. 

[3] Thal, L. J., Carta, A., Clarke, W. R., Ferris, S. H., Friedland, R. P., Petersen, R. C., ... & Woolson, R. F. (1996). A 1-year multicenter placebo-controlled study of acetyl-L-carnitine in patients with Alzheimer's disease. Neurology, 47(3), 705-711.  

[4] Nakazaki, E., Mah, E., Sanoshy, K., Citrolo, D., & Watanabe, F. (2021). Citicoline and memory function in healthy older adults: a randomized, double-blind, placebo-controlled clinical trial. The Journal of nutrition, 151(8), 2153-2160. 

[5] Gutierrez-Mariscal, F. M., de la Cruz-Ares, S., Torres-Peña, J. D., Alcalá-Diaz, J. F., Yubero-Serrano, E. M., & López-Miranda, J. (2021). Coenzyme q10 and cardiovascular diseases. Antioxidants, 10(6), 906.  

[6] Harris, C. B., Chowanadisai, W., Mishchuk, D. O., Satre, M. A., Slupsky, C. M., & Rucker, R. B. (2013). Dietary pyrroloquinoline quinone (PQQ) alters indicators of inflammation and mitochondrial-related metabolism in human subjects. The Journal of Nutritional Biochemistry, 24(12), 2076-2084.  

About our editorial team

The TWC Editorial team is comprised of various wellness practitioners from physiotherapists, acupuncturists, fitness instructors, herbalists, and MDs.

This article does not constitute medical advice. Please consult a healthcare provider for proper diagnosis and treatment.
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