Could Ivermectin + Mebendazole Relieve Chronic Lyme Symptoms?
Recently, our company received a review on our Ivermectin/Mebendazole parasite cleanse. The reviewer shared that it dramatically helped relieve chronic Lyme symptoms—symptoms they had battled since 1990.
That’s 45 years of suffering.
“It was a miracle in my opinion.”
“My Lyme medication helps me deal with symptoms, while Ivermectin + Mebendazole actually made me dramatically stronger and healthier (removed many symptoms).”
It Is Possible—in Theory
Could this combination relieve chronic Lyme symptoms? Theoretically, yes—possibly with fewer and milder side effects than conventional Lyme disease treatments.
Lyme disease is not only the most common but also one of the most disabling tick-borne illnesses. It’s caused by the blacklegged tick (Ixodes scapularis), also known as the deer tick. Lyme disease is now found in all 50 U.S. states. (1)
Map from CDC website. Each dot represents a case of Lyme disease.
Symptoms often mimic the flu, and diagnosis can be missed. If untreated, Lyme can lead to facial paralysis, heart issues, and arthritis. (1)
Chronic Symptoms After Treatment
Even after antibiotics, many patients experience: (2)
- Disabling fatigue
- Muscle aches (knees, wrists, ankles)
- Anxiety and depression
- Heart palpitations
- Dizziness
- Sleep issues
- Brain fog
- Lack of focus
Do Ivermectin or Mebendazole Kill Lyme Disease?
While there’s no evidence yet showing they directly kill Borrelia, both drugs may:
- Target coinfections and vectors
- Modulate the immune system
- Reduce inflammation
How They Work
Ivermectin
- Disrupts chloride channels in parasites
- Paralyzes ticks and worms
- May reduce inflammatory cytokines (TNF-α, IL-6, IL-1β)
(3,4)
Mebendazole
- Blocks tubulin in parasites
- Disrupts microtubules and nutrient absorption
- May induce apoptosis
(5,6,7)
Overlap with Known Lyme Treatments
Some current Lyme meds share similar modes of action:
- Daptomycin – Disrupts membranes (8)
- Clofazimine – Induces oxidative stress (8,9)
- Metronidazole/Tinidazole – DNA and energy disruption
Molecular Mechanism Comparison
| Mechanism | Ivermectin | Mebendazole | Similar Drugs |
|---|---|---|---|
| Ion channel disruption | Alters chloride flow | — | Daptomycin |
| Intracellular transport | Blocks nuclear import | — | Moxifloxacin |
| Cytoskeletal disruption | — | β-tubulin inhibition | Colchicine analogs |
| ATP & redox interference | Oxidative metabolism disruption | Mitochondrial ATP depletion | Clofazimine, Metronidazole |
A Promising Avenue
While not yet proven Lyme treatments, the mechanisms of ivermectin and mebendazole align with drugs known to fight Borrelia.
Disclaimer: Ivermectin and mebendazole are not FDA-approved treatments for Lyme disease. This post is for informational purposes only.
Written by Brooke Lounsbury
