FREE U.S. SHIPPING + NO HIDDEN FEES

Ivermectin Study Published in Anticancer Research Journal : Read Here

Save Up To 50% Off Select Products

Smile

4.8
4.8
Rated 4.8 out of 5 stars
61 Reviews

Smile

4.8
4.8
Rated 4.8 out of 5 stars
61 Reviews

Smile

4.8
4.8
Rated 4.8 out of 5 stars
61 Reviews
$124.99

Email Me When Back In Stock

Smile

Revolutionary Peptide Toothpaste For A Brighter Smile

Checkmark BPC-157 & GHK-Cu Peptides Help Support Gum Health
Checkmark PAP+ for a Whiter Smile
Checkmark Fluoride & Peroxide Free

About Smile Toothpaste 

Smile Toothpaste is a one-of-a-kind formula designed to help support healthy gums and promote a fresher, brighter smile — with a cool, minty flavor.

  • The first peptide-powered toothpaste of its kind: fluoride-free and formulated with PAP+, a gentle whitening agent that's soft on enamel.

  • Features a proprietary blend of peptides, remineralizers, and soothing botanicals like Blue Spirulina and Aloe Vera that may help support gum health, help support tooth remineralization, and gently whiten—all without harsh chemicals.

  • Helps support a healthy-looking smile so you can keep it looking younger, longer.

How To Use

  • Use twice daily, as part of your morning and evening routines. 

  • For optimal results, focus on brushing near the gumline. 

  • Pair with regular flossing and dental checkups for comprehensive oral care. 


SMILE is made with unique, revolutionary ingredients and is not stark white like most drugstore toothpastes. It may vary in color slightly but is a light beige color.

Note: SMILE Toothpaste is formulated with gentle, natural ingredients. However, some users may experience mild gum sensitivity during initial use as the tissue regenerates. Discontinue use if irritation persists and consult your dentist. 

Expert-Backed

Smile Toothpaste was formulated by leading oral health experts to help deliver targeted gum support. The unique blend of BPC-157, GHK-Cu, and hydroxyapatite help support long-term oral health alongside a healthy oral care routine.

Ingredients

Ingredients

Before You Buy

SMILE is formulated with gentle, natural ingredients, but some users may experience mild gum sensitivity during initial use. Discontinue use if irritation persists and consult your dentist. Avoid contact with eyes. For external use by adults only. Keep out of reach of children and pets.

Pairs well with

Spike Support

Spike Support

Get Back to That Pre-COVID feeling

Get Back to That Pre-C...

$58.49
Dental Health Probiotic

Dental Health Probiotic

Support Fresh Breath, Gums and Immune Health

Support Fresh Breath, ...

$44.99
HSA/FSA Eligible with WellnessPay
How It WorksWellnessPay
Three Easy Steps to Using Your HSA/FSA Funds!
1
Simply complete your purchase
2
Click the Wellness Pay link in your order confirmation
3
Sign up to submit your receipts
Standalone Image
Standalone Image

Science-Backed Ingredients

BPC-157

BPC-157

Unique peptide that supports the body’s natural repair processes.

GHK-CU

GHK-CU

A peptide that may help increase blood flow and collagen production.

PAP+

PAP+

Supports healthy remineralization of your teeth.

Standalone Image

Why SMILE Toothpaste?

For A Comfortable Smile

A gentle formula designed to help support healthy gums, so your mouth is less sensitive.

Looking Younger, Longer

Peptides & PAP+ work together to help support a brighter smile and healthy-looking gums.

Support for Strong Teeth

Our peptide blend is crafted to help support strong, healthy gums - so your smile keeps its youthful glow.

Everyday Gum Support

Targeted ingredients help support gum health as part of a consistent oral routine.

For A Comfortable Smile

A gentle formula designed to help support healthy gums, so your mouth is less sensitive.

Looking Younger, Longer

Peptides & PAP+ work together to help support a brighter smile and healthy-looking gums.

Support for Strong Teeth

Our peptide blend is crafted to help support strong, healthy gums - so your smile keeps its youthful glow.

Everyday Gum Support

Targeted ingredients help support gum health as part of a consistent oral routine.

Frequently Asked Questions

How does SMILE work?

SMILE Toothpaste is a first-of-its-kind peptide toothpaste, crafted to help support gum health and a brighter, healthier-looking smile — and it's fluoride free.


Featuring BPC-157 and GHK-Cu, two peptides that have drawn growing interest in the wellness space, alongside PAP+, a peroxide-free whitening agent that's gentle on enamel. Hydroxyapatite rounds out the formula as a naturally derived ingredient that helps support a healthy-looking smile and everyday comfort.


A one-of-a-kind formula, thoughtfully designed to help support your daily oral care routine.

What are the key ingredients?

  • BPC‑157 (Body Protective Compound 157) is a synthetic peptide researched for its effects on tissues in the body, including potential applications in oral wellness. 
  • GHK‑Cu (Glycl-L-Histidyl-L-Lysine Copper) is a copper peptide studied for promoting collagen support and maintaining healthy-appearing tissues. 
  • PAP+ (Phthalimidoperoxycaproic Acid + Hydroxyapatite) is a gentle whitener that is peroxide free to remove stains from teeth, while Hydroxyapatite helps remineralize enamel to reduce sensitivity and support strong teeth. 
  • SMILE also contains antioxidants, vitamins, and minerals like Vitamin C, Vitamin E, CoQ10, Zinc, and Trace Minerals for a holistic approach to oral care! 

Is SMILE safe for dental work?

Yes, SMILE is formulated with gentle ingredients that will support overall oral health.

The peroxide free whitening agent used in SMILE, called PAP+, will not damage crowns, veneers, or dental implants.

PAP+ will not change the color of a crown, veneer, or dental implant as PAP+ will only help to whiten natural teeth.

Why choose SMILE over regular toothpaste?

Smile helps support a healthy-looking smile and keeps it looking younger, longer.

With peptides, remineralizing minerals, and probiotics, this thoughtfully crafted formula is designed to help support gum health, everyday tooth care, and a fresh, balanced mouth feel—finished with a refreshing mint flavor.

How do I use SMILE?

  • Use it twice daily, as part of your morning and evening routines. Apply a pea sized amount on a toothbrush. For optimal results, focus on brushing near the gumline. 
  • Rinsing not required. Some ingredients like hydroxyapatite work best by time on contact.  
  • Pair with regular flossing and dental checkups for comprehensive oral care. 

SMILE is made with unique, revolutionary ingredients and is not stark white like most drugstore toothpastes. It may vary in color slightly but is a light beige color.

WARNING: SMILE is formulated with gentle, natural ingredients, but some users may experience mild gum sensitivity during initial use as the tissue begins to regenerate. Discontinue use if irritation persists and consult your dentist. Avoid contact with eyes. For external use by adults only. Keep out of reach of children and pets.

How many servings per bottle?

Approximately 30 servings per bottle.

Is SMILE allergen free?

SMILE is vegetarian friendly. It is allergen free of milk, eggs, peanuts, tree nuts, fish, wheat, and sesame. 

The Hydrolyzed Collagen Peptides are derived from fish.  

What is the shelf life of this product?

The shelf life of this product is 6 months from the time of manufacture. You can find the Best By (BB) or Expiration (EXP) date printed on the bottom of the bottle along with the lot number.

You May Also Like

$189.99

Roots

4.7
4.7
Rated 4.7 out of 5 stars
10 Reviews

Make Hair Loss Optional

$69.99

Anti-Aging Face Serum

4.9
4.9
Rated 4.9 out of 5 stars
7 Reviews

Illuminating Serum With Peptides & Bakuchiol

$39.99

Whipped Tallow Cream

5.0
5.0
Rated 5.0 out of 5 stars
14 Reviews

Soothing Citrus Vanilla Moisturizer

$199.99

Clear Skin Ivermectin Cream

5.0
5.0
Rated 5.0 out of 5 stars
10 Reviews

Triple-Action Power for Clearer Skin

4.8
Rated 4.8 out of 5 stars
Based on 61 reviews
Total 5 star reviews: 53 Total 4 star reviews: 6 Total 3 star reviews: 2 Total 2 star reviews: 0 Total 1 star reviews: 0
97%would recommend this product
Reviews Summary
Customers say this toothpaste provides noticeable improvements in gum comfort and tooth appearance. Many reviews mention reduced sensitivity, less bleeding, and whiter teeth after regular use. Users frequently report positive feedback from their dentists about improved gum conditions. Common feedback includes satisfaction with the cleaning effectiveness and gentle formula. However, frequent comments address issues with the pump dispenser - many find it inconsistent, difficult to operate, and impossible to gauge remaining product. While most praise the results and plan to continue using it despite the higher price point, the dispenser problems remain a consistent concern.
61 reviews
  • Rated 5 out of 5 stars
    1 month ago
    Definitely best toothpaste in the world!

    I have waited for a few months to share my experience of the best toothpaste in the world. For most of my life, every night I go through a routine that lasts approximately 20 minutes. First, I use interdental little tooth brushes, then unwaxed dental floss, then gum stimulator, then tongue scraper, and finally brushing with electric toothbrush and toothpaste. I see the dental hygienest every three months, and the dentist every six months. They always found plaques, and sometimes cavities. In the past six months (two visits), the dental hygienist has been shocked. She hardly has to do any cleaning and has found no plaques! Definitely, no cavities. She wanted to know what was the name of the toothpaste and looked it up on her phone. The dentist seemed indifferent since he makes a living out of bad teeth!

    ZK
    Zhelah K.
    Verified Buyer
  • Rated 5 out of 5 stars
    1 month ago
    .

    .

    LC
    Lois C. C.
    Verified Buyer
  • Rated 5 out of 5 stars
    1 month ago
    4 months in, my dentists review is GLOWING, and I agree!

    I smoked for over 25 years and had gum disease with some pockets at 5 and 6. After only 4 months of using Smile, my 6's are 5's and some of my 5's are 4's. This product is actually reversing my gum disease. Yes, it's expensive, but implants and losing teeth are way more consequential. The dispenser could definitely use improving, but I will hang in there with results like I am seeing!! SO HAPPY WITH THIS PRODUCT! It has been a miracle find for me!! Oh and it tastes great!

    N
    Nikki
    Verified Buyer
  • Rated 5 out of 5 stars
    1 month ago
    Gums feeling great

    After about 2 weeks using Smile I noticed that a problem I had for many years where food got caught between my teeth and my gums would be irritated had disappeared. I couldn’t be happier!

    JD
    Joanne D.
    Verified Buyer

YOUR CART (0)

No Items in the Cart